Urine test finds what makes people say no to blood pressure lowering pills

(Media Release)  ( free-pr-online.com) University of Manchester researchers together with their UK and overseas collaborators have found out that more than one third of 1,400 people with high blood pressure have not been taking their blood pressure medication.

High blood pressure is the single most important risk factor for health loss and premature death globally, and although treatment is proven to be effective, target blood pressures are only achieved in 40-50% of patients. This is likely to be largely caused by high numbers of patients not taking their medicines correctly, or at all.

The scientists have used a mass-spectrometry technique to examine blood and urine samples from almost 1,400 people in the UK and Czech Republic.

They found that non-adherence to the blood pressure lowering drugs was high at 41.6% in the UK and 31.5% in the Czech Republic. Furthermore, with each additional prescription, the rate of non-adherence increased by 85% and 77% respectively.

Professor Maciej Tomaszewski from The University of Manchester, who led the study, said: “We suspected that some patients haven’t’ been taking their medications on a regular basis but this analysis shows how high that figure is.

“Clearly, the more blood pressure lowering drugs are prescribed, the higher the risk that the patients will not be taking them on a regular basis. We also showed that diuretics are particularly poorly taken.”

The results from this analysis, show that four easy-to-collect parameters: patients’ age, sex, the number of blood pressure lowering medications and the diuretics together can provide a good measure of the risk of not taking the medications on a regular basis.

The researchers believe that in the future they can develop even better formulae to estimate the risk of not taking blood pressure lowering drugs without a need of a urine/blood analysis.

This will be particularly useful in countries with limited resources, as Professor Tomaszewski explained. “Not all countries will have sufficient expertise and the financial capacity to invest in technology that we are using.”

Professor Tomaszewski’s research team has just been awarded £750,000 by the British Heart Foundation to further the understanding of non-adherence to antihypertensive treatment.

Professor Tomaszewski said: “We are thrilled by this generous award from the British Heart Foundation. Our collaborative OUTREACH study brings together the key UK centres and researchers in the field of hypertension to examine how our urine test can help patients taking their blood pressure lowering medications on a regular basis.”

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New findings on formation, malformation of blood vessels

(Media Release) In diseases like cancer, diabetes, rheumatism and stroke, a disorder develops in the blood vessels that exacerbates the condition and obstructs treatment. Researchers at Karolinska Institutet now show how blood vessels can normally change their size to create a functional circulatory system and how vascular malformation during disease can occur. In the study, published in Nature Cell Biology, the researchers managed to treat vascular malformation in mice, a discovery of potential significance to numerous vascular diseases.

A healthy body has a perfect balance of arteries, capillaries and veins that allow the blood to reach every cell in the body and that form what is called the “vascular tree.” New blood vessels are formed by endothelial cells, which normally coat the inside of blood vessels and which organise themselves into tubes and mature, along with other cells, into arteries, capillaries or veins.

Throughout a person’s life, the vascular tree has to adapt its branches to the changing needs of body tissue, such as during growth, muscle building or wound healing. However, there are diseases that affect the endothelial cells in a way that throws the vascular tree out of balance, which exacerbates the disease and often causes haemorrhaging. In cancer, for example, it is known that the vessels leak and direct shunts form between arteries and veins, preventing drugs from reaching the tumour.

To understand how arteries, veins and capillaries are created — and how the process malfunctions in the presence of disease — the researchers studied normal vascular formation and the inherited Osler-Weber-Rendu disease (HHT), which is characterised by vascular malformation and repeated haemorrhaging, with an increased risk of stroke. By switching signals on and off in the endothelial cells of genetically manipulated mice, the researchers could describe how the protein Endoglin controls vascular formation and malformation. They found that the protein acts like a sensor that detects blood flow and tells the endothelial cells to organise themselves into veins, capillaries or arteries as necessary. Cells that lacked the protein were less able to form arteries.

The researchers were also able to reduce vascular malformation in the genetically manipulated mice.

“Our findings contribute to the understanding of fundamental biological processes that explain how the vascular tree is formed and what causes vascular malformation,” says Lars Jakobsson, assistant professor at Karolinska Institutet’s Department of Medical Biochemistry and Biophysics. “Drugs with a similar effect as one of those we tested are currently used to treat patients with inherited vascular malformation but are still under evaluation. Now we have another candidate and a more nuanced idea of how it works. We are  ( free-pr-online.com) now in a better position to control the formation and malformation of blood vessels and thus their function, which can eventually lead to improved treatments for a number of diseases.”

The researchers at Karolinska Institutet also contributed to a parallel study, published in the same issue of Nature Cell Biology, describing how blood flow influences endothelial cell size that in turn affects vessel identity and malformation.

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Intensive blood pressure can reduce risk of harm to heart muscle

(Media Release) A new study by researchers at Wake Forest Baptist Medical Center has shown that aggressive lowering of blood pressure in people with hypertension reduced the risk of left ventricular hypertrophy (LVH). This condition, the enlargement and thickening of the walls of the heart’s main pumping chamber, is the most common complication of high blood pressure and greatly increases the risk of developing cardiovascular disease.

The study is published in the early online edition of the journal Circulation.

“We know that high blood pressure could lead to LVH and we know that lowering this pressure to the recommended levels improves it, but we didn’t know if intensive lowering of blood pressure beyond recommended would lead to more improvement in heart muscle,” said Elsayed z. Soliman, M.D., lead author of the study and director of the epidemiological cardiology research center at Wake Forest School of Medicine, a part of Wake Forest Baptist.

The objective of the study was to determine if lowering blood pressure below what is generally recommended would lead to more benefits to the heart muscle in terms of thickening (hypertrophy). And if so, would it also prevent other cardiovascular events.

The research team examined these questions through analysis of 8,164 participants from the National Institutes of Health’s Systolic Blood Pressure Intervention (SPRINT) trial, which included patients with hypertension  ( free-pr-online.com) but not diabetes. Participants were randomized to the intensive blood pressure lowering group or the standard treatment group.

Study findings showed that lowering systolic blood pressure to less than120 mmHg compared to the standard recommendation of 140 mmHg prevented development of new LVH in those without it and caused regression of LVH in those who already had it.

“We thought that reducing heart muscle thickening would correlate with fewer heart incidents associated with intensive lowering of high blood pressure, but surprisingly that was not the case,” Soliman said.

“However, this favorable impact on heart muscle did not explain most of the reduction in cardiovascular events associated with intensive blood pressure lowering. More research is needed to understand what factors determine which patients get the most benefits and less of the harm.”

These findings provide further evidence of the benefits of the intensive blood pressure lowering in patients with hypertension, and suggest that these benefits go beyond reducing the pressure and stress on the heart structure.

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Cb Response Defends South Korean Special Prosecutor’s Office from Targeted Cyberattacks During Impeachment of Former President Park Geun-hye

FOR IMMEDIATE RELEASE

Free Press Release Submitted by carbonblack.com


 

 

 

 

 

 

Press Release Distribution

Naru Security leverages Carbon Black’s market leading EDR solution
to identify malicious activity and catch attempted data exfiltration

WALTHAM, Mass.—May 16, 2017—Carbon Black, the leader in
next-generation endpoint security, today announced that the
company’s market-leading endpoint detection and response (EDR)
solution, Cb Response, was leveraged by local authorities during the
prosecution and impeachment of former South Korean President Park
Geun-hye. ( free-pr-online.com)

Through a relationship with Korean security partner, Naru Security
Inc., Carbon Black collaborated with the special prosecutor’s office
to provide end-to-end endpoint monitoring with Cb Response, defending
the office from targeted cyberattacks.

Park, the first woman to be elected as president of South Korea, was
impeached in December and officially stripped of power in March. She
was recently indicted on bribery, extortion, abuse of power and other
high-profile corruption charges. Former human rights attorney and
student activist, Moon Jae-in, was elected as Park’s replacement on
May 9.

“Park’s impeachment was a global affair being tracked by millions
of news consumers,” said Kane Lightowler, Carbon Black’s managing
director, Asia Pacific. “Given how high profile this case was, there
were many risks to the special prosecutor’s office. There was
concern that Park’s supporters might attempt to delete or taint
evidence and the risk of other cyberattackers hoping to profit by
leaking the latest evidence to the media. By leveraging Cb Response,
Naru Security gained valuable insight into nefarious endpoint activity
and kept the prosecutor’s office safe during an unsettling time.
Increasingly, governments and political organizations around the world
are turning to Carbon Black to protect their most sensitive
information.”

From December through February, Naru Security deployed Cb Response
across all of the special prosecutor’s office’s endpoints and
integrated Cb Response with the network solution ConnecTome to collect
data and visualize it end-to-end. Cb Response identified and confirmed
numerous malicious activities on the office’s endpoints, stopping
the potential destruction of critical trial evidence.

“In the early stages of monitoring, we identified malicious
activities via ConnecTome and pinpointed the process and MD5 with Cb
Response,” said Joon Kim, Naru Security’s CEO. “Moreover,
unknown attempted data exfiltration was identified by Cb Response.
Carbon Black offered valuable insight during a time of great political
unrest in South Korea.”

About Cb Response

Cb Response is the most precise IR and threat hunting solution for SOC
practitioners, allowing them to get the answers they need faster than
any other tool. Only Cb Response continuously records and captures all
threat activity so security teams can hunt threats in real time,
visualize the complete attack kill chain, and then respond and
remediate attacks quickly. The result is zero-gap endpoint visibility.
Investigations are accelerated because the information needed is
always available with conclusive answers to investigation questions.
With Cb Response, alert validation and triage are streamlined because
the details of what caused an alert are at responders’ fingertips.

Cb Response was recently named Best Endpoint Detection and Response
Solution by security professionals in the SANS Institute’s Best of
2016 Awards.

About Carbon Black
Carbon Black is the leading provider of next-generation endpoint
security. With more than 9 million endpoints under management, Carbon
Black has more than 3,000 customers, including 30 of the Fortune 100.
These customers use Carbon Black to replace legacy antivirus, lock
down critical systems, hunt threats, and protect their endpoints from
the most advanced cyberattacks, including non-malware attacks.
Contact:

Asia Pacific and Japan Requests
Venelyn Chin
+65 3157 5627
[email protected]

North America Requests
Ryan Murphy
917-693-2788
[email protected]

Vocab Tunes Biweekly Dance Contest Begins May 15th

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Free Press Release Submitted by vocabtunes.com


 

 

 

 

 

 

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The biweekly Vocab Tunes’ dance contest will begin for school kids
(preschool to 8th grade), aged between 5-14 years from 05-15-2017 to
05-28-2017.  ( free-pr-online.com)

A report of US Education Department showed continuous erosion in
vocabulary skills among young students across the nation. The report
reveals a steady decline of vocabulary knowledge among school kids for
the past 50 years in spite of a huge amount of money being spent on
it. Making a change to this dreadful situation, Vocab Tunes’ online
learning programs play a significant role by making kids aware about
the Greek and Latin root Words thereby expanding their English
vocabulary.

To make learning an easy and fun activity, Vocab Tunes has come up
with an exciting concept of biweekly dance contest for schoolchildren.
The sole aim of this competition is to make kids fall in love with
learning new English words while making some creative moves to the
select educative songs of Vocab Tunes.

The first biweekly dance contest begins May 15, for kids of ages
between 5-14 years. Students from preschool to 8th grade can
participate in the contest. They can choose any of 21 Vocab Tunes’
songs and can submit their dance video clips from 05-15-2017 to
05-28-2017. Winner will be selected through online voting procedure,
which will begin from 05-29-2017. One lucky winner of each biweekly
contest will be awarded a cash prize of $100.

In a recent interview, Vocab Tunes’ author Dr. Manisha Shelley Kaura
points out that “lack of root knowledge in school kids is the reason
behind the decline of vocabulary skills. A Xavier University,
Cincinnati alumnus Manisha says, “Singing and dancing is a whole
mind/body experience, also students are more interested in learning
through music and songs other than monotonous classroom activities.
Therefore while preparing our Vocab Tunes’ programs we focused on
making it a melodious learning activity.”

Manisha along with her father Dr. S.R. Kaura, a practicing family
physician in Southgate, created a four-level K-12 vocabulary program
to help kids enhance vocabulary. The father-daughter duo has even
authored two vocabulary textbooks named ‘Rockin’ Root Words’
(Prufrock Press, 2010) to help young minds enrich their vocabulary
skills.

Details of First Biweekly Dance Contest

05.15.2017—05.28.2017 Submission of video clips

05.29.2017—06.11.2017 Voting for your favorite contestant via social
media logins

06.12.2017 and 06.13.2017 Announcement of winners and prize
distribution

About Vocab Tunes:

A father-daughter duo initiative, Vocab Tunes, aims at making learning
root words an easy and fun activity for schoolchildren. An advocate
for educational reformer in Michigan and Ohio, Dr. Manisha Shelly
kaura along with her physician father Dr. S.R. Kaura started this
online learning program to help kids stock new words and expand their
vocabulary through singing and dancing. http://vocabtunes.com/

Sunbase Homes Promises Cash Offers For Homes In 24 Hours

FOR IMMEDIATE RELEASE

Free Press Release Submitted by southernnevadahomebuyers.com


 

 

 

 

 

 

 

Press Release Distribution

Las Vegas, NV  ( free-pr-online.com) May 15, 2017 – Sellers in and
around Las Vegas, including Henderson, North Las Vegas, and Boulder
City can now get a cash quote in less than 24 hours when they call
Sunbase Homes cash home buyer.

“We buy foreclosed houses for sale in Las Vegas for cash and promise
to close in less than two weeks. Our services are perfect for sellers
who are desperately looking to get out of a sticky situation. They
might be facing foreclosure or are trying to move into a new place.
Some of our clients have inherited homes that they cannot afford to
keep,” adds a spokesperson for Sunbase Homes. “Our specialty is
finding ways out of these situations that are easy and profitable for
the homeowner.”

From investigating titles and arranging closing formalities to
after-sale cleaning, the company manages everything. Homeowners don’t
pay closing costs or attorney fees. “We make sure you don’t have to
pay any real estate commissions or waste your money on pre-sale
repairs,” he says. Sunbase Homes have been buying homes for more
than a decade and have closed hundreds of homes. They also work with
banks in helping owners out of a short sale.

“We do not hassle owners with repeat calls. Our quotes are strictly
non-obligation. Homeowners are free to reject the offer. Our
specialists will explain the process and how they have arrived at the
offer price before a client signs the agreement,” he adds.

About Sunbase Homes

Sunbase Homes is a real estate investment company; we buy houses for
cash in and around Las Vegas, including Boulder County and Henderson.
This is a locally-owned family business that has helped hundreds of
homeowners get out of sticky situations.

For more information, visit http://www.southernnevadahomebuyers.com/

###

A Community Comes Together in the Delightful Children’s Story “Have You Seen Henry?”

FOR IMMEDIATE RELEASE

Free Press Release Submitted by halopublishing.com


 

 

 

 

 

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Author Michael Worley has been creating stories and drawing cartoons
since he was a little boy. ( free-pr-online.com)

Dallas, TX (USA), May 13th, 2017 — Author Michael Worley has been
creating stories and drawing cartoons since he was a little boy. His
imagination has spawned several other children’s stories including
“Sonny the Scarecrow”, “The Quiet Giant”, “A Dog’s
Tale”, “Everett the Piano” and “Lacey Shoestring’s Amazing
Red Wagon Adventure.” In “Have You Seen Henry?” Worley was
inspired by an actual possum encounter in his backyard.

“There was something so intriguing and fun about the possum that
wandered into my backyard that I couldn’t resist featuring him in a
children’s story,” said Worley. “I love animals and how they
interact and as I was writing the story of Henry I began to imagine a
community of animals within a neighborhood who are willing to work
together for a common good.”

Each of the characters in “Have You Seen Henry?” are beautifully
brought to life by illustrator Jorge Chiquillo. Worley uses repetition
and clever alliteration with each character’s name like Frieda Fox,
Amy Armadillo, and Roger Rooster which help children remember a
growing number of adorable animals who come to the aide of Henry’s
wife, Henrietta. As the story progresses and tensions mount, Worley
shows how friends can encourage and support each other even in
difficult times.

“I hope children will learn a lesson in the value of friendship,”
said Worley. “In my life I have seen first hand the benefits of
willing to help others in their time of need. I believe it is an
especially important lesson for children to learn from a young age.
Rather than finding fault, we should look for ways to come together
with kindness, generosity and friendship.”

“Michael has written such a fun story that children will want to
read it over and over,” said Lisa Umina, founder and president of
Halo Publishing International. “Each page of the story introduces a
new character, building a growing community of friends who are on a
hunt for the missing Henry. Children and parents will laugh out loud
at the conclusion when they discover Henry in the last place
imaginable.”

Worley is hard at work creating a new story about an unlikely alien
named George the Goon that he hopes will be brought to life in a
feature length animated movie. In the meantime, look for upcoming
sequels to “Lacey Shoestring’s Amazing Red Wagon Adventure” and
the further adventures of Rex the Dog and Rudy the Rabbit from “A
Dog’s Tale.”

“Have You Seen Henry?” is now available at Halo Publishing, Amazon
and Barnes and Noble, in hard cover for $17.95.

* Halo Publishing –
http://halopublishing.com/7t-z/michael-d.-worley.html

* Amazon –
https://www.amazon.com/Have-Seen-Henry-Michael-Worley/dp/1612445667/ref=sr_1_1?s=books&ie=UTF8&qid=1493842073&sr=1-1

* Barnes and Noble –
http://www.barnesandnoble.com/w/have-you-seen-henry-michael-d-worley/1126325945?ean=2940157570446

About Michael Worley:
The passion for writing stories and drawing cartoons started for
Michael Worley while he was just a child. Michael is the author of
Sonny the Scarecrow, Everett the Piano, The Quiet Giant, A Dog’s
Tale, Lacey Shoestring’s Amazing Red Wagon Adventure, and Have You
Seen Henry? Michael owned and operated Pyramid Productions, Inc., in
Dallas, Texas for fourteen years. He produced script-to-screen turnkey
film and video productions for corporate and commercial advertising.
Michael presently owns and operates a successful residential property
management company located in Dallas, Texas.

About Halo Publishing International:
Halo Publishing International is a self-publishing company that
publishes adult fiction and non-fiction, children’s literature,
self-help, spiritual, and faith-based books. We continually strive to
help authors reach their publishing goals and provide many different
services that help them do so. http://www.HaloPublishing.com

Press & Media Contact:
Lisa M. Umina, Publisher
Halo Publishing International
1100 NW Loop 410, Suite 700-176
San Antonio, TX 78213 – USA
+1 877-705-9647
[email protected]
http://www.halopublishing.com

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